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Allium cepa , a fiber-rich herb believed to have originated in Afghanistan, Iran, and the former Soviet Union (170), is traditionally used to treat HTN in various countries, including Ethiopia (62, 63), Morocco (171), as well as Algeria, Benin, Brazil, Congo, Italy, Kosovo, Martinique, Mexico, Nigeria, Pakistan, Peru, the Philippines, Romania, Spain, Togo, and Turkey (172)

However, our observations revealed no substantial differences in RIP1 and RIP3 levels, indicating hepsin's role may not involve necroptosis modulation (Fig

doi: 10.1371/journal.pone.0145453 234 Manfredo VieiraSHiltenspergerMKumarVZegarra-RuizDDehnerCKhanNet al